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Related Concept Videos

Coronavirus01:29

Coronavirus

Coronaviruses, including the severe acute respiratory syndrome coronavirus (SARS-CoV), are enveloped viruses characterized by their single-stranded, positive-sense RNA genome and helical nucleocapsid structure. The hallmark of these viruses is their club-shaped spike (S) glycoproteins that protrude from the viral envelope, facilitating attachment to host cells. Typically, coronaviruses infect the upper respiratory tract, often causing mild or asymptomatic disease. However, certain strains like...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...

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Related Experiment Video

Updated: Jul 8, 2026

Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection
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Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection

Published on: June 5, 2021

SARS coronavirus anti-infectives.

Tommy R Tong1

  • 1Department of Pathology, Princess Margaret Hospital, Hong Kong. tommy.tong@yahoo.com

Recent Patents on Anti-Infective Drug Discovery
|January 29, 2008
PubMed
Summary

Severe acute respiratory syndrome (SARS) is a potential re-emerging infectious disease. Research is advancing drug discovery and patent applications for treatments targeting SARS-coronavirus (SARS-CoV) infection.

Area of Science:

  • Virology
  • Infectious Diseases
  • Drug Discovery

Background:

  • Severe acute respiratory syndrome (SARS) emerged in 2002, caused by SARS-coronavirus (SARS-CoV), and was controlled by public health measures.
  • SARS-CoV has the potential for re-emergence due to its animal reservoir origin.
  • Understanding viral proteins, cellular receptors, and host interactions is crucial for developing therapeutics.

Purpose of the Study:

  • To review recent advances and inventions targeting SARS-CoV infection in humans.
  • To highlight the significance of patent applications for potential SARS-CoV treatments.

Main Methods:

  • Review of scientific literature and patent applications.
  • Analysis of drug targets and therapeutic strategies against SARS-CoV.

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Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

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Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

Main Results:

  • Discovery of promising lead drugs and novel uses for existing drugs.
  • Increased relevance of patent applications for cathepsin L inhibitors due to their role in viral entry.
  • Identification of patent applications for SARS-CoV protease inhibitors, interferon, and mismatched dsRNA as potential treatments.

Conclusions:

  • Advances in understanding SARS-CoV biology have led to new therapeutic strategies.
  • Patent applications indicate significant ongoing research and development for SARS-CoV treatments.
  • Continued monitoring of these inventions is essential for the prevention and treatment of SARS-CoV infections.