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Updated: Jul 8, 2026

An In Vitro Approach to Photodynamic Therapy
Published on: August 17, 2018
Photodynamic therapy in the treatment of actinic keratosis
Andrea Stritt1, Hans Friedrich Merk, Lasse Roger Braathen
1Department of Dermatology, Inselspital, University of Bern, Bern, Switzerland.
Abstract:
The efficacy of photodynamic therapy (PDT) with 5-aminolevulinate and methyl aminolevulinate in the treatment of actinic keratosis has been demonstrated in a large number of clinical studies over the last several years. Here, we recapitulate the major findings, comparing the various photosensitizers, light sources and therapeutic regimens, and present a retrospective analysis of 142 own cases treated with 259 PDTs. In addition, we also discuss the value of PDT in comparison with cryotherapy or 5-fluorouracil. The efficacy and the low risk of side effects of PDT have resulted in a high patient preference in clinical trials.
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