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Related Concept Videos

Amebiasis01:28

Amebiasis

Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Microbiome of the Eye01:22

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The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...

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Updated: Jul 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Bilateral acanthamoeba keratitis.

Kirk R Wilhelmus1, Dan B Jones, Alice Y Matoba

  • 1Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, 6565 Fannin Street, Houston, TX 77030, USA. kirkw@bcm.tmc.edu

American Journal of Ophthalmology
|January 29, 2008
PubMed
Summary
This summary is machine-generated.

Bilateral Acanthamoeba keratitis, an infection affecting both eyes, is linked to contact lens use. Prompt diagnosis and treatment can often restore vision in affected patients.

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Published on: September 20, 2024

Area of Science:

  • Ophthalmology
  • Infectious Diseases

Background:

  • Acanthamoeba keratitis (AK) is a serious microbial infection of the cornea.
  • Contact lens wear is a primary risk factor for AK.
  • Binocular involvement in AK is uncommon but can lead to severe visual impairment.

Purpose of the Study:

  • To investigate the prevalence and characteristics of binocular Acanthamoeba keratitis.
  • To identify risk factors and outcomes associated with bilateral AK.
  • To understand the clinical presentation of AK affecting both eyes.

Main Methods:

  • Retrospective case series analysis.
  • Review of consecutive AK cases diagnosed between 1997 and 2007.
  • Exploration of risk factors and outcomes in patients with bilateral infection.

Main Results:

  • Eleven percent (5/45) of patients presented with bilateral AK.
  • Bilateral cases included concurrent and successive corneal involvement.
  • Contact lens wear (soft and rigid gas-permeable) was noted in binocularly infected patients.
  • Nine out of ten affected eyes achieved good visual acuity (≥20/30) after treatment.

Conclusions:

  • Bilateral AK is an infectious complication associated with contact lens wear.
  • Early laboratory confirmation and medical management are crucial for visual recovery.
  • Prompt antiamebic therapy can lead to favorable visual outcomes in most cases.