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Updated: Jul 7, 2026
07:15
An Intact Pericardium Ischemic Rodent Model
Published on: September 2, 2021
Effect of pericardial blood processing on postoperative inflammation and the complement pathways
Bertrand Marcheix1, Michel Carrier, Catherine Martel
1Department of Cardiovascular Surgery, Montreal Heart Institute and University of Montreal, Montreal, Quebec, Canada.
The Annals of Thoracic Surgery
|January 29, 2008
Summary
Cell-saving devices (CS) reduce postoperative inflammation by decreasing complement alternative pathway activation during cardiopulmonary bypass (CPB). This study investigated CS and vacuum-assisted CPB effects on inflammation markers.
Area of Science:
- Cardiovascular Surgery
- Immunology
- Biomedical Engineering
Background:
- Cardiopulmonary bypass (CPB) surgery can trigger postoperative inflammation.
- Investigating methods to mitigate this inflammatory response is crucial for patient outcomes.
Purpose of the Study:
- To evaluate the impact of cell-saving devices (CS) and vacuum-assisted cardiopulmonary bypass (VACPB) on reducing inflammation after coronary artery bypass grafting (CABG).
Main Methods:
- A prospective randomized study involving 100 patients undergoing on-pump CABG.
- Patients were assigned to four groups: no CS/VACPB, VACPB only, CS only, or both CS and VACPB.
- Complement factors (C4a, C3a, C5a, sC5b-9, MBL, Bb) were measured preoperatively and post-CPB.
Main Results:
- All groups showed increased C3a, sC5b-9, and Bb, and decreased C5a and MBL post-CPB.
- Bb levels were significantly lower at 240 minutes in patients using CS (p = 0.0002).
Conclusions:
- CPB significantly activates complement pathways and their terminal components.
- Cell-saving devices (CS) effectively reduce the activation of the complement alternative pathway.
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