Related Experiment Video
Updated: Jul 7, 2026

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
Published on: March 27, 2018
Postoperative internal thoracic artery spasm after coronary artery bypass grafting
Ralf E Harskamp1, Jeffrey D McNeil, Margreet W van Ginkel
1Division of Cardiothoracic Surgery, Department of Surgery, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, USA. r.e.harskamp@gmail.com
Insights
Left internal thoracic artery spasm is a serious complication after coronary artery bypass grafting. Intra-arterial nitroglycerin and verapamil effectively treated this vasospasm in a recent case study.
Area of Science:
- Cardiovascular Surgery
- Vascular Physiology
Background:
- Coronary artery bypass grafting (CABG) is a common surgical procedure.
- Graft selection is crucial for long-term patency and patient outcomes.
- Thoracic artery grafts are frequently used in CABG procedures.
Observation:
- Perioperative spasm of the left internal thoracic artery (LITA) can occur after CABG.
- This vasospasm is a potentially life-threatening complication.
- Spasm is typically more common in radial artery grafts.
Findings:
- A case of LITA graft spasm was successfully treated with intra-arterial nitroglycerin and verapamil.
- This demonstrates the efficacy of specific vasodilators in managing LITA spasm.
- LITA grafts, like radial artery grafts, are susceptible to vasospasm.
Implications:
- Early recognition and prompt treatment of LITA spasm are essential.
- Pharmacological management with vasodilators can resolve LITA graft spasm.
- Understanding the propensity for vasospasm in LITA grafts can inform surgical technique and postoperative care.
Abstract:
Spasm of the left internal thoracic artery in the perioperative period represents a life-threatening complication after coronary artery bypass grafting. We present a case in which graft spasm was treated with the administration of intra-arterial nitroglycerin and verapamil. Although vasospasm is more often seen in radial artery grafts, this case demonstrates that left internal thoracic artery grafts are also prone to spasm.
Related Concept Videos
Peripheral Artery Disease V: Postoperative Nursing Management
Aneurysm III: Interprofessional Care
Aneurysm II: Clinical Manifestations and Diagnostic Studies
Aneurysm IV: Nursing Management
Coronary Artery Disease V: Interprofessional Care
Cardiac Catheterization II: Right Heart Catheterization
