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The glomerular response to IgA deposition in IgA nephropathy

Ivan C Moura1, Marc Benhamou, Pierre Launay

  • 1Inserm U699, Paris, France.

Seminars in Nephrology
|January 29, 2008
PubMed
Summary

IgA receptors, including the transferrin receptor (TfR) and FcalphaRI (CD89), play key roles in IgA nephropathy pathogenesis. Their interactions with IgA immune complexes drive mesangial cell proliferation and inflammation, contributing to disease progression.

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