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Updated: Jul 7, 2026

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
Published on: November 15, 2013
NSAIDs revisited: putative molecular basis of their interactions with peroxisome proliferator-activated gamma
Nelilma C Romeiro1, Carlos M R Sant'Anna, Lidia M Lima
1LASSBio--Laboratório de Avaliação e Síntese de Substâncias Bioativas, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro (UFRJ), P.O. Box 68006, 21941-902 Rio de Janeiro, RJ, Brazil. ncorrea@pharma.ufrj.br
Abstract:
This paper describes molecular docking studies of a series of classical NSAIDs with PPARgamma receptor, which has been pointed as a new target for the design of anti-cancer and anti-inflammatory drugs, and has been found to be responsible for some of the already established pharmacological effects observed for marketed drugs. The results show the molecular basis of PPARgamma activation by non-selective COX inhibitors.
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