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Triptans in pregnancy.

Offie P Soldin1, Julia Dahlin, Daniel M O'Mara

  • 1Department of Medicine, Georgetown University Medical Center, Washington, DC 20057, USA. os35@georgetown.edu

Therapeutic Drug Monitoring
|January 29, 2008
PubMed
Summary
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Triptan medications for migraines show no evidence of causing birth defects in pregnant individuals. However, studies indicate a potential increase in preterm birth rates associated with triptan use during pregnancy.

Area of Science:

  • Pharmacology
  • Obstetrics
  • Neurology

Background:

  • Triptans are serotonin (5-hydroxytriptamine) (5-HT) agonists used for migraine treatment.
  • Seven triptan medications are available in the U.S.: almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, and zolmitriptan.

Purpose of the Study:

  • To investigate the safety and effects of triptan use during pregnancy.
  • To review existing data on triptan utilization in pregnant populations.

Main Methods:

  • Review of available literature and manufacturer-maintained pregnancy registries.
  • Analysis of data concerning sumatriptan use, given its longer market presence and potential higher usage.

Main Results:

  • No teratogenic effects have been identified for any triptan medications.

Related Experiment Videos

  • An elevated rate of preterm birth appears to be associated with triptan use in pregnancy.

    • Conclusions:

    • Current data do not suggest triptans cause birth defects.
    • Further research is warranted to fully understand the risks and benefits of triptans in pregnancy, particularly regarding preterm birth.