Painless thyrotoxic thyroiditis in association with ovarian and adrenal failure

Polyglandular autoimmune syndrome (PGAS) type II is a disorder characterized by Addison's disease, autoimmune thyroid disease, and diabetes mellitus. In this report, a 19-year-old woman having Addison's disease, ovarian failure, painless thyroiditis, and an HLA type characteristic of PGAS II is described. Painless thyroiditis has been considered recently to have an autoimmune basis and has been reported previously in another patient with Addison's disease. The otherwise characteristic features of the patient in this case allow her to be classified as having PGAS II, thereby expanding the scope of reported autoimmune thyroid disorders in PGAS II.