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Detection and Visualization of DNA Damage-induced Protein Complexes in Suspension Cell Cultures Using the Proximity Ligation Assay
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p21(WAF1/CIP1) induction by 5-azacytosine nucleosides requires DNA damage

A Jiemjit1, T E Fandy, H Carraway

  • 1The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21231, USA.

Oncogene
|January 29, 2008
PubMed
Summary

Decitabine (DAC) upregulates p21(WAF1/CIP1) expression through a DNA damage pathway, independent of DNA methyltransferase inhibition. This mechanism involves the ATM/p53 axis, leading to cell cycle arrest and apoptosis in leukemia cells.

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