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Related Experiment Video

Updated: Jul 7, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

Link between obstructive sleep apnea and increased bone resorption in men.

H Tomiyama¹, R Okazaki, D Inoue

¹Second Department of Internal Medicine, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan. tomiyama@tokyo-med.ac.jp

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

|January 29, 2008

Summary

Obstructive sleep apnea (OSA) is linked to abnormal bone metabolism, with higher bone resorption markers in severe cases. Continuous positive airway pressure (CPAP) therapy significantly reduced these markers, indicating a potential treatment benefit.

Related Experiment Videos

Last Updated: Jul 7, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

Area of Science:

Endocrinology and Metabolism
Sleep Medicine
Orthopedics

Background:

Obstructive sleep apnea (OSA) is characterized by hypoxia, microinflammation, and oxidative stress, all known to impact bone metabolism.
Previous research suggests a connection between OSA and altered bone metabolism, but direct evidence and the effects of treatment were unclear.

Purpose of the Study:

To investigate bone metabolic abnormalities in patients with obstructive sleep apnea (OSA).
To evaluate the impact of continuous positive airway pressure (CPAP) therapy on these bone abnormalities.

Main Methods:

A study involving 50 male OSA patients and 15 age-matched controls.
Measurement of plasma cytokines (IL-1beta, IL-6, TNF-alfa), oxidative stress markers (3-nitrotyrosine), bone formation markers (osteocalcin, BAP), and bone resorption marker (urinary CTX).
Measurements were taken before and after 3 months of CPAP therapy in OSA patients.

Main Results:

Patients with severe OSA exhibited higher plasma cytokine and urinary CTX levels compared to mild OSA or control groups.
Following 3 months of CPAP therapy, a significant reduction in urinary CTX excretion and plasma cytokine levels was observed in OSA patients.
These findings suggest a direct link between OSA severity and bone resorption.

Conclusions:

The study provides the first evidence directly linking obstructive sleep apnea (OSA) to abnormal bone metabolism.
Severity-dependent increases in bone resorption markers in OSA patients were reversed by CPAP therapy.
CPAP therapy may help mitigate bone metabolic disturbances associated with OSA.