Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chromatin regulation by AML1 complex.

Hitoshi Yoshida1, Issay Kitabayashi

  • 1Molecular Oncology Division, National Cancer Center Research Institute, Chuo-Ku, Tokyo 104-0045, Japan.

International Journal of Hematology
|January 29, 2008
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Directional Bias in Polyp Detection during Colonoscopy: A Prospective Observational Study.

Digestion·2026
Same author

Enhancer of zeste 2 polycomb repressive complex 2 subunit overexpression suppresses apoptosis in canine T-cell lymphoma: an <i>in vitro</i> functional analysis.

Frontiers in veterinary science·2026
Same author

ALBI Grade is a Determinant of Lenvatinib Pharmacokinetics, Efficacy, and Toxicities in Japanese Patients with Hepatocellular Carcinoma.

Clinical pharmacokinetics·2026
Same author

Recurrent Mutations in Protein Tyrosine Phosphatase Receptor Type Kappa (PTPRK) in Depressed-Type Colorectal Carcinomas.

Journal of biochemistry·2026
Same author

Clathrin-associated SCYL2 contributes to the activation of PI3K/AKT signaling and tumorigenesis through PTEN phosphorylation in adult T-cell leukemia/lymphoma.

Cancer gene therapy·2026
Same author

Long-term administration of the mutant IDH inhibitor DS-1001b suppresses the growth of IDH1-mutant glioma in vitro and in mouse xenograft models and alters epigenetic profiles.

Acta neuropathologica·2026
Same journal

Cytarabine-based induction and oral maintenance therapy for a single system with single-site Langerhans cell histiocytosis.

International journal of hematology·2026
Same journal

Long-term treatment-free remission in CML after early dasatinib discontinuation due to interstitial pneumonitis.

International journal of hematology·2026
Same journal

Correction to: Low reticulocyte count at infusion is a risk factor for high-grade cytokine release syndrome in chimeric antigen receptor T cell therapy.

International journal of hematology·2026
Same journal

The efficacy of prophylactic tranexamic acid in patients with hematologic malignancy: a systematic review and meta-analysis.

International journal of hematology·2026
Same journal

Current status and challenges of TCR-T cell therapy for AML/MDS.

International journal of hematology·2026
Same journal

Efficacy and safety of maribavir in Japanese patients with post-transplant cytomegalovirus infections: a phase III study.

International journal of hematology·2026
See all related articles

The AML1 gene is crucial for blood formation and gene regulation. Leukemia-associated translocations disrupt the AML1 complex, leading to chromatin structure deregulation and disease.

Area of Science:

  • Molecular Biology
  • Genetics
  • Hematology

Background:

  • The AML1 gene is frequently targeted in chromosomal translocations associated with acute leukemias.
  • AML1 is vital for definitive hematopoiesis and controls gene transcription via DNA binding.
  • AML1 forms multiprotein complexes with core components like CBFbeta and regulatory factors including p300/CBP, MOZ, PML, and HIPK2.

Purpose of the Study:

  • To review the mechanisms of AML1 complex in regulating gene transcription and hematopoiesis.
  • To examine how leukemia-associated chromosomal translocations disrupt AML1 complex function.
  • To explore the role of AML1 complex disruption in chromatin structure deregulation.

Main Methods:

  • Literature review of studies on AML1 gene, hematopoiesis, and acute leukemias.

Related Experiment Videos

  • Analysis of mechanisms underlying AML1 complex-mediated gene transcription.
  • Examination of the impact of chromosomal translocations on AML1 complex components.

    • Main Results:

    • AML1 complex orchestrates gene transcription and hematopoiesis through interactions with chromatin modulators.
    • Chromosomal translocations affecting AML1 complex genes lead to its disruption.
    • Disruption of the AML1 complex contributes to the deregulation of chromatin structure in leukemia.

    Conclusions:

    • The AML1 complex is a key regulator of hematopoiesis and gene expression.
    • Leukemia-associated translocations targeting AML1 components disrupt normal cellular processes.
    • Understanding these disruptions offers insights into leukemia pathogenesis and potential therapeutic targets.