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Updated: Jul 7, 2026

Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke
Published on: January 3, 2025
[Neurodegeneration in experimental stroke--involvement of apoptosis-regulating proteins]
Dorota Sulejczak1, Małgorzata Skup
1Zakład Neurofizjologii, Instytut Biologii, Doświadczalnej im. M. Nenckiego PAN. dorotas@cmdik.pan.pl
Abstract:
The article presents the state of the art based on experimental studies in vivo and concerning the mechanisms of stroke-induced neurodegeneration in the brain. Molecular bases of differences in brain regions affected indirectly and directly by cortical ischaemia are also discussed. Proteins which may play a key role in apoptosis, including the Bcl-2 protein family, are described in relation to their responses to the infarct. Finally, therapeutic perspectives connected with modulation of function of these proteins are outlined.
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