Related Experiment Video
Updated: Jul 7, 2026

Cortical Source Analysis of High-Density EEG Recordings in Children
Published on: June 30, 2014
Theory and generalization of Monte Carlo models of the BOLD signal source
John Martindale1, Aneurin J Kennerley, David Johnston
1Centre for Signal Processing in Neuroimaging and Systems Neuroscience, Department of Psychology, University of Sheffield, Sheffield, UK.
Abstract:
The dependency of the blood oxygenation level dependent (BOLD) signal on underlying hemodynamics is not well understood. Building a forward biophysical model of this relationship is important for the quantitative estimation of the hemodynamic changes and neural activity underlying functional magnetic resonance imaging (fMRI) signals. We have developed a general model of the BOLD signal which can model both intra- and extravascular signals for an arbitrary tissue model across a wide range of imaging parameters. The model of the BOLD signal was instantiated as a look-up-table (LuT), and was verified against concurrent fMRI and optical imaging measurements of activation induced hemodynamics.
Related Concept Videos
Signal and System
Propagation of Uncertainty from Random Error
Superposition Theorem
Propagation of Uncertainty from Systematic Error
Mechanistic Models: Compartment Models in Individual and Population Analysis
Theory of Attribution I: Correspondent Inference Theory

