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Related Experiment Video

Updated: Jul 7, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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Testosterone replacement therapy for older men.

Stephen E Borst1, Thomas Mulligan

  • 1Geriatrics Research, Education, and Clinical Center, North Florida/South Georgia Veterans Health System, Gainesville, FL, USA. seborst@ufl.edu

Clinical Interventions in Aging
|January 30, 2008
PubMed
Summary

Testosterone therapy in older men shows mixed results, with benefits seen primarily in those with low testosterone levels. Current evidence does not support general use, but future research may identify specific patient groups who can benefit.

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Published on: December 28, 2021

Area of Science:

  • Endocrinology
  • Geriatrics
  • Metabolic Health

Background:

  • Many older men exhibit partial androgen deficiency.
  • Low testosterone correlates with reduced muscle strength, increased adiposity, insulin resistance, and cognitive decline.
  • Existing testosterone replacement studies show inconsistent benefits.

Purpose of the Study:

  • To evaluate the efficacy and safety of testosterone therapy in older men.
  • To identify factors influencing treatment outcomes, such as dosage, duration, and patient selection.
  • To explore potential benefits for specific hypogonadal populations.

Main Methods:

  • Review of existing research on testosterone replacement therapy in older men.
  • Analysis of studies employing varying doses, durations, and patient cohorts.
  • Assessment of anabolic responses compared to resistance exercise training.

Main Results:

  • Testosterone replacement has shown modest anabolic effects, often less than resistance exercise.
  • Higher doses and longer durations, targeting men with low baseline testosterone, yield better results.
  • Adverse effects include sleep apnea, gynecomastia, polycythemia, and elevated PSA.

Conclusions:

  • Testosterone therapy is not recommended for the general older male population.
  • Hypogonadal older men may benefit, particularly those with specific medical conditions.
  • Ongoing assessment of efficacy and adverse effects is crucial for patients undergoing therapy.