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Related Concept Videos

Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...

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A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease
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Angiogenesis in inflammatory bowel disease.

I D Pousa1, J Maté, J P Gisbert

  • 1Department of Gastroenterology and Ciberehd, University Hospital of La Princesa, Universidad Autónoma Madrid, Spain.

European Journal of Clinical Investigation
|January 30, 2008
PubMed
Summary

Inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease, involve intestinal microvascular remodelling. Understanding pathological angiogenesis in inflammatory bowel diseases may lead to better therapies.

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Area of Science:

  • Gastroenterology
  • Vascular Biology
  • Immunology

Background:

  • Ulcerative colitis and Crohn's disease are complex inflammatory bowel diseases (IBD) with unclear pathogenesis.
  • Current theories involve genetic, microbial, immune factors, and intestinal microvascular remodelling (angiogenesis).

Purpose of the Study:

  • To explore the role of intestinal microvascular remodelling and angiogenesis in the pathogenesis of inflammatory bowel diseases.
  • To investigate how abnormal angiogenesis may sustain chronic intestinal inflammation.

Main Methods:

  • Review of recent molecular evidence and proposed theories on IBD pathogenesis.
  • Analysis of the interplay between physiological and pathological angiogenesis in the context of intestinal damage and inflammation.

Main Results:

  • Intestinal damage triggers physiological angiogenesis.
  • Aberrant expression of angiogenic molecules and altered vascular cell types suggest pathological vascular remodelling in IBD.
  • Pathological angiogenesis may promote and perpetuate inflammation in IBD.

Conclusions:

  • Intestinal microvascular remodelling, specifically pathological angiogenesis, is implicated in IBD pathogenesis.
  • Further understanding of angiogenic processes could inform the development of novel therapeutic strategies for chronic intestinal inflammation.