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Anchoring the genome
Diego Ottaviani1, Elliott Lever, Petros Takousis
1Cancer Research UK London Research Institute, Lincoln's Inn Fields, London WC2A 3PX, UK.
Genome Biology
|January 30, 2008
Abstract:
Although the principles governing chromosomal architecture are largely unresolved, there is evidence that higher-order chromatin folding is mediated by the anchoring of specific DNA sequences to the nuclear matrix. These genome anchors are also crucial regulators of gene expression and DNA replication, and play a role in pathogenesis.
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