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Updated: Jul 7, 2026

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
Published on: July 8, 2025
Predicting the conformations of peptides and proteins in early evolution. A review article submitted to Biology
E James Milner-White1, Michael J Russell
1Institute of Biomedical and Life Sciences, University of Glasgow, G12 8QQ, UK. J.Milner-White@bio.gla.ac.uk
Abstract:
Considering that short, mainly heterochiral, polypeptides with a high glycine content are expected to have played a prominent role in evolution at the earliest stage of life before nucleic acids were available, we review recent knowledge about polypeptide three-dimensional structure to predict the types of conformations they would have adopted. The possible existence of such structures at this time leads to a consideration of their functional significance, and the consequences for the course of evolution.
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