Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

3.4K
Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult...
3.4K
The Extracellular Matrix01:42

The Extracellular Matrix

88.9K
Overview
88.9K
The Extracellular Matrix01:29

The Extracellular Matrix

12.2K
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
12.2K
Extracellular Matrix01:26

Extracellular Matrix

5.4K
Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
5.4K
Role of Septins01:02

Role of Septins

2.2K
Septins are the recently discovered fourth major protein component of the cytoskeleton, along with microfilaments, microtubules, and intermediate filaments. These proteins can associate with other cytoskeletal filaments and carry out varied roles or can be free-floating in the cytoplasm.
Cellular Functions of Septins
Recent studies have revealed the multifaceted roles of septins in various cellular processes such as cytokinesis, ciliogenesis, and neurogenesis. Septins act as scaffolds and...
2.2K
The Bone Matrix01:18

The Bone Matrix

5.7K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
5.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immune System of the Ischemic Brain: Old Paradigms Revisited.

Stroke·2026
Same author

Endovascular administration and magnetic retention of nanocapsules for improved brain delivery in large cerebral vascular models.

Nanoscale·2026
Same author

Biomarker Differences in Aneurysmal Subarachnoid Hemorrhage: A Comparative Study of Patients with and Without Delayed CEREBRAL Ischemia.

Neurocritical care·2025
Same author

Extracellular vesicle proteomics identifies novel blood biomarkers for the early diagnosis of status epilepticus.

Epilepsia·2025
Same author

Identifying new blood biomarkers of neuroplasticity associated with rehabilitation outcomes after stroke.

Scientific reports·2025
Same author

Combination of alpha-1 antitrypsin (A1AT) and anti-TNFα as a neuroprotective strategy in the early stages after ischemic stroke.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2025

Related Experiment Video

Updated: Jan 31, 2026

Author Spotlight: Advances in Nanoscale Infrared Spectroscopy to Explore Multiphase Polymeric Systems
06:54

Author Spotlight: Advances in Nanoscale Infrared Spectroscopy to Explore Multiphase Polymeric Systems

Published on: June 23, 2023

1.3K

Multiphasic roles for matrix metalloproteinases after stroke.

Anna Rosell1, Eng H Lo

  • 1Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. anna.rosell@gmail.com

Current Opinion in Pharmacology
|January 30, 2008
PubMed
Summary
This summary is machine-generated.

Matrix metalloproteinases (MMPs) are key in brain injury and recovery after stroke. Targeting MMPs acutely may harm recovery, suggesting a nuanced therapeutic approach is needed for stroke patients.

More Related Videos

Measuring Global Cellular Matrix Metalloproteinase and Metabolic Activity in 3D Hydrogels
07:39

Measuring Global Cellular Matrix Metalloproteinase and Metabolic Activity in 3D Hydrogels

Published on: January 22, 2019

7.9K
Detection of Functional Matrix Metalloproteinases by Zymography
09:30

Detection of Functional Matrix Metalloproteinases by Zymography

Published on: November 8, 2010

85.0K

Related Experiment Videos

Last Updated: Jan 31, 2026

Author Spotlight: Advances in Nanoscale Infrared Spectroscopy to Explore Multiphase Polymeric Systems
06:54

Author Spotlight: Advances in Nanoscale Infrared Spectroscopy to Explore Multiphase Polymeric Systems

Published on: June 23, 2023

1.3K
Measuring Global Cellular Matrix Metalloproteinase and Metabolic Activity in 3D Hydrogels
07:39

Measuring Global Cellular Matrix Metalloproteinase and Metabolic Activity in 3D Hydrogels

Published on: January 22, 2019

7.9K
Detection of Functional Matrix Metalloproteinases by Zymography
09:30

Detection of Functional Matrix Metalloproteinases by Zymography

Published on: November 8, 2010

85.0K

Area of Science:

  • Neuroscience
  • Biochemistry
  • Pathology

Background:

  • Matrix metalloproteinases (MMPs) are zinc-dependent enzymes crucial for extracellular matrix regulation in the central nervous system (CNS).
  • MMPs play significant roles in both normal CNS development and pathological processes, including acute tissue injury like stroke.
  • Dysregulation of MMPs post-stroke contributes to neurovascular damage and brain tissue destruction.

Purpose of the Study:

  • To investigate the dual role of matrix metalloproteinases (MMPs) in the acute and delayed phases following stroke.
  • To evaluate the therapeutic potential of targeting MMPs for stroke treatment.
  • To explore the impact of MMP activity on neurovascular remodeling and stroke recovery.

Main Methods:

  • Analysis of data from gene knockout models in stroke.
  • Pharmacologic experiments targeting MMP activity.
  • Review of emerging data on MMPs in neuroinflammation and recovery.

Main Results:

  • MMPs are implicated in acute neurovascular disruption and parenchymal destruction after stroke.
  • Gene knockout and pharmacologic studies suggest MMPs as potential therapeutic targets for stroke.
  • Evidence indicates MMPs may also facilitate beneficial neurovascular remodeling and stroke recovery during delayed inflammatory responses.

Conclusions:

  • Matrix metalloproteinases (MMPs) exhibit complex roles in stroke, mediating both acute damage and delayed recovery.
  • Therapeutic strategies targeting MMPs for stroke require careful consideration to balance acute inhibition with the promotion of endogenous repair mechanisms.
  • A nuanced approach to modulating MMP activity is essential for optimizing outcomes after stroke, avoiding interference with beneficial remodeling processes.