Related Experiment Video

Updated: Jul 7, 2026

Isolation and Physiological Analysis of Mouse Cardiomyocytes
11:02

Isolation and Physiological Analysis of Mouse Cardiomyocytes

Published on: September 7, 2014

Cytokines and myocardial dysfunction: state of the art

Ayman A El-Menyar1

  • 1Weill Cornell Faculty of Medicine, Doha, Qatar.

Journal of Cardiac Failure
|January 30, 2008
PubMed

Insights

Cytokines play a role in myocardial dysfunction. Current anticytokine treatments are not recommended for advanced heart failure, necessitating further research for optimal cytokine and immunomodulation therapy timing.

Area of Science:

  • Cardiology
  • Immunology
  • Pathophysiology

Background:

  • Myocardial dysfunction is linked to inflammation and altered cytokine levels.
  • Cytokines are key mediators in cardiovascular disease processes.

Purpose of the Study:

  • To elucidate the role of cytokines in the development and treatment of myocardial dysfunction.
  • To review current understanding of cytokine involvement in heart failure.

Main Methods:

  • Systematic literature review of Medline, Scopus, Cochrane Database, and EBSCO Host.
  • Analysis of published articles concerning heart failure and cytokine modulation.

Main Results:

  • Proinflammatory cytokines require further investigation for diagnostic and therapeutic applications.
  • Anticytokine therapy is not advised for patients with advanced heart failure currently.

Conclusions:

  • Further research is essential to determine the optimal timing for cytokine and immunomodulation therapies.
  • Understanding cytokine roles is crucial for future heart failure management strategies.
Abstract

More Related Videos

Coronary Artery Ligation and Intramyocardial Injection in a Murine Model of Infarction07:41

Coronary Artery Ligation and Intramyocardial Injection in a Murine Model of Infarction

Published on: June 7, 2011

A Simple and Effective Method to Consistently Isolate Mouse Cardiomyocytes06:25

A Simple and Effective Method to Consistently Isolate Mouse Cardiomyocytes

Published on: November 11, 2022

Related Concept Videos

Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...