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Multilaboratory testing of antifungal combinations against a quality control isolate of Candida krusei

Vishnu Chaturvedi1, Rama Ramani, Mahmoud A Ghannoum

  • 1Mycology Laboratory, Wadsworth Center, New York State Department of Health, 120 New Scotland Ave., Albany, NY 12208, USA. vishnu@wadsworth.org

Antimicrobial Agents and Chemotherapy
|January 30, 2008
PubMed

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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...