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High level ciprofloxacin resistance in Salmonella enterica isolated from blood

R Raveendran1, C Wattal, A Sharma

  • 1Department of Clinical Microbiology, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi - 110 060, India.

Indian Journal of Medical Microbiology
|January 30, 2008
PubMed
Abstract

Insights

Ciprofloxacin resistance in Salmonella Typhi is a growing concern. Ceftriaxone is now the primary treatment for these resistant infections.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Ciprofloxacin resistance in Salmonella enterica is a significant global health issue.
  • Understanding local susceptibility patterns is crucial for effective treatment.

Purpose of the Study:

  • To determine the antimicrobial susceptibility patterns of Salmonella enterica isolates in a hospital setting.
  • To assess the prevalence of ciprofloxacin resistance in Salmonella Typhi and Paratyphi A.

Main Methods:

  • Blood cultures analyzed using BacT/ALERT 3D system.
  • Antimicrobial susceptibility testing via Kirby-Bauer disc diffusion and CLSI breakpoints.
  • Minimum inhibitory concentration determined for resistant strains using E-test and Vitek-1.

Main Results:

  • 431 Salmonella Typhi and 198 Salmonella Paratyphi A isolates identified.
  • 5.6% of Salmonella Typhi isolates showed ciprofloxacin resistance (22/431).
  • All isolates remained susceptible to ceftriaxone, while resistance to older antibiotics like ampicillin, chloramphenicol, and co-trimoxazole has decreased.

Conclusions:

  • Ciprofloxacin is no longer the preferred treatment for Salmonella infections.
  • Ceftriaxone is the recommended treatment for ciprofloxacin-resistant Salmonella infections.
  • While first-line antimicrobials may retain some utility, ceftriaxone offers reliable efficacy against resistant strains.

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