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Related Experiment Video

Updated: Jul 7, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Androgens and the aging male.

Stuart N Seidman¹

¹Department of Psychiatry, Columbia University, New York City, NY, USA.

Psychopharmacology Bulletin

|January 30, 2008

Summary

Aging men experience a progressive decline in testosterone, leading to hypogonadism (andropause) and associated symptoms like sexual dysfunction. Testosterone replacement may offer some symptom relief, but its link to depression is unclear.

Area of Science:

Endocrinology
Andrology
Geriatrics

Background:

Men experience a gradual decline in hypothalamic-pituitary-gonadal (HPG) axis function with age, unlike the abrupt menopause in women.
Testosterone levels decrease due to central and peripheral factors, with loss of circadian rhythm and at least 25% of men over 70 meeting criteria for hypogonadism.

Purpose of the Study:

To review the relationship between androgens, depression, and sexual function in aging men.
To explore the concept of andropause and its associated symptoms.

Main Methods:

Review of cross-sectional and longitudinal studies on male aging and HPG axis function.
Analysis of literature linking testosterone levels to symptoms like fatigue, reduced muscle/bone mass, sexual dysfunction, and depression.

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Murine Prostate Micro-dissection and Surgical Castration

Murine Prostate Micro-dissection and Surgical Castration

Published on: May 11, 2016

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Last Updated: Jul 7, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Murine Prostate Micro-dissection and Surgical Castration

Murine Prostate Micro-dissection and Surgical Castration

Published on: May 11, 2016

Main Results:

Age-associated HPG hypofunctioning (andropause) is linked to various symptoms in elderly men.
Testosterone replacement shows potential benefits for muscle strength, bone density, and erectile dysfunction.
Evidence for a link between HPG axis hypofunctioning and depression is weak, with inconsistent antidepressant effects of androgens.

Conclusions:

Andropause is characterized by declining testosterone and associated symptoms in aging men.
Testosterone therapy may alleviate certain physical and sexual symptoms.
The connection between declining androgens and depression in aging men requires further investigation.