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Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

Beyond prostate-specific antigen: alternate serum markers.

M L Ramírez¹, E C Nelson, C P Evans

¹Department of Urology and Cancer Center, Davis Medical Center, University of California at Davis, Sacramento, CA 95817, USA.

Prostate Cancer and Prostatic Diseases

|January 30, 2008

Summary

Improving early prostate cancer (CaP) diagnosis requires new methods beyond prostate-specific antigen. Recent molecular assays and proteomic profiling show promise for identifying aggressive disease and improving patient outcomes.

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Quantitation of Protein Expression and Co-localization Using Multiplexed Immuno-histochemical Staining and Multispectral Imaging

Published on: April 8, 2016

Area of Science:

Oncology
Biomarker Discovery
Molecular Diagnostics

Background:

Current prostate cancer (CaP) diagnostic methods, including prostate-specific antigen (PSA) testing, have limitations in accurately detecting early-stage disease and predicting aggressive cancer.
There is a significant clinical need for improved serum-based biomarkers to enhance CaP diagnosis and risk stratification.
Previous research examining serum analytes as alternatives or supplements to PSA has yielded limited clinically useful data.

Purpose of the Study:

To review the current state of serum biomarkers for prostate cancer (CaP) diagnosis and prognosis.
To evaluate the benefits and limitations of existing and emerging CaP serum markers.
To highlight the potential of novel technologies like proteomic array profiling and DNA methylation assays.

Main Methods:

Literature review of existing data on serum analytes for prostate cancer detection.
Analysis of recent technological advancements in molecular assays and their impact on biomarker discovery.
Discussion of proteomic profiling and DNA methylation assays as future diagnostic and prognostic tools.

Main Results:

While many serum analytes have been investigated, few have demonstrated sufficient clinical utility to replace or supplement prostate-specific antigen (PSA).
Recent technological advances have led to the identification of prospective markers with improved specificity for CaP detection.
Proteomic array profiling and DNA methylation assays show considerable promise for more accurate CaP diagnosis and prognosis.

Conclusions:

Novel molecular assays and proteomic approaches offer significant potential for advancing prostate cancer (CaP) diagnostics and prognostics.
Further research and validation are needed for emerging biomarkers to establish their clinical utility.
The field of proteomics holds promise for discovering more accurate markers for CaP management.