Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hypersensitivity Reactions: Immune-Complex Reactions

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...

Allergic Reactions: Anaphylaxis

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...

Allergic Drug Reactions

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...

Allergic Reactions

Allergic Reactions

Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

Soundness of Cement

Soundness of Cement

The soundness of cement refers to the ability of cement paste to retain its volume after setting. Unsound cement can lead to expansion and structural damage due to the presence of free lime, magnesia, and calcium sulfate. Free lime hydrates very slowly, expanding and causing unsoundness, which is difficult to detect because it intercrystallizes with other compounds. Magnesia also reacts with water, forming crystals that can disrupt the cement's structure. Calcium sulfate can create ettringite,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

High-risk molecular features may eclipse genomic complexity in predicting chronic lymphocytic leukemia outcomes; UK clinical trial insights.

Leukemia·2026

Same author

2025 British Society for Haematology Guideline for the treatment of chronic lymphocytic leukaemia.

British journal of haematology·2025

Same author

A Systematic Approach to Prioritise Diagnostically Useful Findings for Inclusion in Electronic Health Records as Discrete Data to Improve Clinical Artificial Intelligence Tools and Genomic Research.

Clinical oncology (Royal College of Radiologists (Great Britain))·2025

Same author

CUBITAL TUNNEL SYNDROME DUE TO AN INTRANEURAL GANGLION CYST OF THE ULNAR NERVE.

Georgian medical news·2023

Same author

TRAUMATIC PULMONARY HERNIATION: A RARE CHEST TRAUMA MANIFESTATION.

Georgian medical news·2023

Same author

AN INTRATENDINOUS GANGLION CYST OF THE PATELLAR TENDON: A RARE CAUSE OF ANTERIOR KNEE PAIN.

Georgian medical news·2023

Search research articles

Related Experiment Videos

[Allergy to bone cement components].

P Thomas¹, A Schuh, R Eben

¹Klinik und Poliklinik für Dermatologie und Allergologie , Ludwig-Maximilians-Universität, Frauenlobstrasse 9-11, 80337, München, Deutschland. Peter.Thomas@med.uni-muenchen.de

|January 30, 2008

Summary

This summary is machine-generated.

Bone cement components can trigger implant allergies. Testing for bone cement allergens like gentamicin and benzoyl peroxide is recommended for patients with suspected hypersensitivity reactions to arthroplasty.

Related Experiment Videos

Area of Science:

Allergology
Orthopedics
Biomaterials Science

Context:

Intolerance reactions to endoprostheses often lead to allergological diagnostics.
Current diagnostics primarily focus on metal allergies.
Bone cement contains potential allergens like acrylates, additives (e.g., benzoyl peroxide), and antibiotics (e.g., gentamicin).

Purpose:

To investigate the prevalence of contact allergies to bone cement components in patients with cemented prostheses.
To evaluate the role of bone cement components in hypersensitivity reactions to arthroplasty.

Summary:

A study at Munich implant allergy clinic examined 113 patients with cemented prostheses.
24.8% (28 patients) showed contact allergies to bone cement components.
Gentamicin (16.8%) and benzoyl peroxide (BPO) (8.0%) were the most common allergens.

Impact:

Highlights the significant prevalence of bone cement allergies.
Suggests expanding diagnostic protocols for implant hypersensitivity.
Recommends including bone cement components in allergological workups for suspected arthroplasty reactions.