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Responses to sympathetic stimulation and tilting during antihypertensive treatment with nisoldipine
F Pasanisi1, S Soro, L A Ferrara
1Institute of Internal Medicine and Metabolic Diseases, Second Medical School, University of Naples, Italy.
Abstract:
Nisoldipine is a calcium antagonist of the dihydropyridine group under investigation for treatment of hypertension. The authors have assessed the cardiovascular response to adrenergic stimulation by isometric exercise, cold pressor test and 70 degrees head-up tilt on four occasions: following placebo, acute and chronic administration of nisoldipine 5 mg or 10 mg o.d. in eighteen mild to moderately hypertensive patients (13 M, 5 F; age range 28-69 years). Blood pressure and heart rate were measured by automatic recorder. Blood pressure was significantly decreased at 2 h after administration of nisoldipine. Blood pressure maximal response at 3 min during isometric exercise following nisoldipine 10 mg chronic was significantly lower, compared to placebo as well as to a 5 mg dose (172/105 +/- 13/8 with 10 mg vs. 182/116 +/- 21/14 with 5 mg and 182/113 +/- 18/11 with placebo; p less than 0.05). Cardiovascular response to the cold pressor test showed a similar pattern; head-up tilt did not cause hypotension. The results of this study suggest that administration of nisoldipine in hypertensive patients slightly attenuates the pressor response to sympathetic stimulation by isometric exercise.
Insights
Nisoldipine, a dihydropyridine calcium antagonist, was studied in hypertensive patients. It was found to slightly reduce blood pressure and attenuate the pressor response to sympathetic stimulation during isometric exercise.
Area of Science:
- Cardiovascular Pharmacology
- Hypertension Management
Background:
- Nisoldipine is a dihydropyridine calcium antagonist.
- It is under investigation for treating hypertension.
Purpose of the Study:
- To assess the cardiovascular response to adrenergic stimulation (isometric exercise, cold pressor test, head-up tilt) after placebo, acute, and chronic administration of nisoldipine (5 mg or 10 mg once daily).
Main Methods:
- Eighteen mild to moderately hypertensive patients participated.
- Cardiovascular responses were measured following placebo, acute, and chronic nisoldipine administration.
- Blood pressure and heart rate were recorded automatically.
Main Results:
- Nisoldipine significantly decreased blood pressure at 2 hours post-administration.
- Chronic 10 mg nisoldipine significantly lowered maximal blood pressure response during isometric exercise compared to placebo and 5 mg dose.
- Cardiovascular response to cold pressor test showed a similar pattern; head-up tilt did not induce hypotension.
Conclusions:
- Nisoldipine administration in hypertensive patients slightly attenuates the pressor response to sympathetic stimulation induced by isometric exercise.