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Updated: Jul 7, 2026
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The Chick Chorioallantoic Membrane In Vivo Model to Assess Perineural Invasion in Head and Neck Cancer
Published on: June 21, 2019
The chick chorioallantoic membrane as an in vivo angiogenesis model
M Lourdes Ponce1, Hynda K Kleinmann
1National Institutes of Health Bethesda, Maryland, USA.
Current Protocols in Cell Biology
|January 30, 2008
Abstract:
The chick chorioallantoic membrane (CAM) assay for angiogenic activity is a model originally developed to study the angiogenic activity of tumor samples. It is an in vivo assay that can be readily performed in any laboratory setting. The effects of a test compound on angiogenesis are tested by exposing day 10 embryos to the compound and following the patterns of blood vessel development, scoring the appearance of the CAM at day 12 or 13.
