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Serum elastase-type enzymes and their correlation to blood lipids in male patients with atherosclerosis
A Landi1, M Bihari-Varga, L Keller
11st Department of Medicine, St. Stephen Hospital, Budapest, Hungary.
Insights
Patients with ischemic vascular disease show lower serum elastase activity and higher elastase inhibitory capacity. Lipid levels, including HDL cholesterol and apo A, correlate negatively with elastase inhibitory capacity in these patients.
Area of Science:
- Biochemistry
- Cardiovascular Medicine
- Vascular Biology
Background:
- Ischemic vascular disease encompasses coronary, cerebral, and peripheral artery conditions.
- Elastase activity and inhibition are implicated in vascular health.
- Lipid profiles, including HDL cholesterol and apolipoprotein A, are known risk factors for cardiovascular disease.
Purpose of the Study:
- To investigate serum elastase-type activity and elastase inhibitory capacity in male patients with ischemic vascular disease.
- To examine the relationship between these enzymatic markers and lipid profiles in patients and controls.
Main Methods:
- Assessed serum elastase-type activity and elastase inhibitory capacity in 140 male patients with ischemic vascular disease and 60 controls.
- Analyzed correlations between enzymatic markers and lipid parameters such as HDL cholesterol, HDL2 cholesterol, and apo A concentration.
Main Results:
- Patients with ischemic vascular disease exhibited significantly lower serum elastase-type activity compared to controls.
- Conversely, patients showed significantly higher elastase inhibitory capacity than the control group.
- A significant negative correlation was observed between HDL cholesterol, HDL2 cholesterol, apo A concentration, and elastase inhibitory capacity in both patient and control groups.
Conclusions:
- Altered serum elastase activity and inhibitory capacity are associated with ischemic vascular disease.
- Lipid profiles, particularly HDL cholesterol and apo A, are inversely related to elastase inhibitory capacity, suggesting a potential link between lipid metabolism and protease regulation in vascular disease pathogenesis.
Abstract:
Serum elastase-type activity, elastase inhibitory capacity and their relation to lipids were examined in 140 male patients with ischaemic vascular disease (coronary, cerebral, peripheral) and in 60 control subjects. Serum elastase-type activity was found to be significantly lower, inhibitory capacity significantly higher, in the groups of patients than in the controls. HDL- and HDL2 cholesterol as well as apo A concentration showed significant negative correlation with elastase inhibitory capacity both in atherosclerotic and in control subjects.