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K Cobbaert1, A Pieters, M Devinck

  • 1Departement reumatologie, Universitair Ziekenhuis Gent, De Pintelaan 185, 9000 Gent, België. debruyne-cobbaert@telenet.be

Acta Clinica Belgica
|January 31, 2008
PubMed

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The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...