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Updated: Jul 7, 2026

Screening and Isolation of C-Glycoside-Cleaving Intestinal Bacteria
Published on: February 28, 2025
[A new coumarin glycoside from Glehnia littoralis]
1Department of Analysis of Traditional Chinese Medicine, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
Abstract:
To study the chemical constituents from Glehnia littoralis, macroreticular resin column chromatography, repeated column chromatography on Sephadex LH-20 and reverse phase ODS were used to isolate the compounds whose structures were elucidated based on spectroscopic data (ESI-MS, 1D and 2D NMR). A new coumarin glycoside was isolated and identified as: bergaptol 5-O-beta-D-gentiobioside (1), along with eight known compounds: (7R, 8S)-dehydrodiconiferylalcohol-4, 9-di-O-beta-D-glucoside (2), cirtrusin A (3), (-)-seco-isolariciresinol 4-O-beta-D-glucopyranoside (4), baihuaqianhuside (5), xanthotoxol 8-O-beta-D-glucopyranoside (6), 5'-methylthioadenosine (7), adenosine (8), L-tryptophan (9). Compound 1 is a new coumarin glycoside, compounds 2 and 7 were isolated from this genus for the first time.
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