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Updated: Jul 7, 2026

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
[A new software method for accurate mass measurements of drugs on unit mass resolution mass spectrometer]
Ke Liu1, Bin Ma, Yong-dong Wang
1Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Abstract:
Accurate mass measurements of 20 drugs were conducted using MassWorks software on a TSQ Quantum Ultra mass spectrometer. All Q1 scan mass spectral data were collected in profile mode with full width at half-maximum (FWHM) set at 0.7 Da. The mass errors of all 20 drugs (molecular weight between 135 and 810) were within the range from -22.4 x 10(-6) to 36. 1 x 10(-6), among them 90% of the drugs achieved a mass accuracy better than 10 x 10(-6). The new method can provide accurate mass measurements on unit mass resolution mass spectrometers.
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