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Published on: February 14, 2018
In vitro antifungal activity of 2,5 disubstituted amino-oksometyloso-arylo-thiadiazole derivatives
C Lukaszuk1, E Krajewska-Kułak, A Niewiadomy
1Department of General Nursing, Medical Academy in Białystok, Poland. cecylia.lukaszuk@wp.pl
Purpose:
The aim of the study was the determination of antifungal activity of new of 2,5 disubstituted amino-oksometyloso-arylo-thiadiazole (AOAT) derivatives against Candida albicans, non-Candida albicans.
Material And Methods:
The determination of antifungal activity AOATs against 20 Candida albicans, 18 non-Candida albicans was performed. Isolates were from different ontocenoses of patients were used for tests. AOATs were synthesized at Department of Chemistry University of Agriculture in Lublin.
Results:
The mean MIC of AOATs against Candida albicans strains was 141.625 (37.5-200) mg/L on Sabouraud's medium (SB). The mean MIC of AOATs against non-Candida albicans strains was 153.3 (50-200) mg/L.
Conclusion:
It seems that AOATs exert potent antifungal activity against the yeast-like fungi strains in vitro.
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