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Updated: Jul 7, 2026

Analysis of SEC-SAXS data via EFA deconvolution and Scatter
Published on: January 28, 2021
A comparison of deconvolution and windowed subtraction techniques for scatter compensation in SPECT
J C Yanch1, M A Flower, S Webb
1Dept. of Phys., Inst. of Cancer Res. and R. Marsden Hospital, Sutton.
Abstract:
Three procedures for the removal of Compton-scattered data in SPECT by constrained deconvolution are presented. The first is a deconvolution of a 2-D measured PSRF containing scatter from a single reconstructed transaxial image; the second is a deconvolution of a 2-D measured point-source response function (PSRF) from each frame of projection data prior to reconstruction; the third involves deconvolution of a 3-D measured PSRF from a stack of reconstructed slices. Results of applying these procedures to data obtained from a phantom containing cold cylinders and to data from a cold spot-resolution phantom are presented and are shown to be superior to the results of correcting for scatter by scatter-window substraction. Both 3-D deconvolution from reconstructed images and 2-D deconvolution from projection data show major improvements in image contrast, resolution, and quantitation. Improvements are especially marked for small (1.0-3.0 cm) cold sources.
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