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[Imatinib and solid tumours]

Samia Arifi1, Hiba El Sayadi, Armelle Dufresne

  • 1Unité de jour d'oncologie médicale multidisciplinaire, pavillon E, Hôpital Edouard-Herriot, 5 place d'Arsonval, 69003 Lyon, France.

Bulletin Du Cancer
|January 31, 2008
PubMed

Imatinib mesylate (Gleevec, Glivec, Novartis, Basel, Switzerland) is a small molecule inhibitor of the tyrosine kinase c-abl, c-kit and the platelet derived growth factor receptor (PDGFR). Imatinib was developed for the treatment of chronic myeloid leukaemia (CML) but was approved both in Europe and the US fro the treatment of CML and gastrointestinal stromal tumors (GIST). Given its activity against both c-kit and PDGFR kinases and its remarkable safety profile, imatinib has been 'tried' in several solid tumors; results however have often been deceiving. We review the current data regarding the activity of imatinib in solid tumors, including GIST.

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