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Lymphotoxin 252A>G polymorphism is common and associates with myocardial infarction in patients with rheumatoid

V F Panoulas1, S N Nikas, J P Smith

  • 1Department of Rheumatology, Dudley Group of Hospitals NHS Trust, Russells Hall Hospital, Dudley, West Midlands, UK.

Annals of the Rheumatic Diseases
|January 31, 2008
PubMed

Insights

Rheumatoid arthritis (RA) patients have a higher prevalence of the LT-A 252GG genotype, which is linked to an increased risk of myocardial infarction. This genetic factor may contribute to the higher cardiovascular disease (CVD) rates in RA.

Area of Science:

  • Genetics and Rheumatology
  • Cardiovascular Disease Research

Background:

  • Rheumatoid arthritis (RA) significantly increases the risk of cardiovascular disease (CVD) and mortality.
  • Genetic factors, specifically single nucleotide polymorphisms (SNPs) in lymphotoxin-A (LT-A) and galectin-2 (LGALS2), are implicated in CVD risk in the general population.

Purpose of the Study:

  • To investigate if LT-A and LGALS2 risk genotypes are more frequent in RA patients compared to controls.
  • To determine if these genotypes are associated with prevalent CVD within the RA patient cohort.

Main Methods:

  • Genomic DNA was collected from 388 RA patients and 399 population controls.
  • Real-time PCR and melting curve analysis identified LT-A gene intron 1 252A>G and LGALS2 intron 1 3279C>T SNPs.

Main Results:

  • The LT-A 252GG genotype was significantly more prevalent in RA patients (19.8%) than controls (11.8%).
  • RA patients with the LT-A 252GG genotype had a higher likelihood of myocardial infarction compared to those with other LT-A genotypes.
  • LGALS2 polymorphisms showed no significant difference between groups or association with CVD in RA patients.

Conclusions:

  • The LT-A 252GG genotype is more common in RA patients than in the general population.
  • This genotype is associated with an increased risk of myocardial infarction in individuals with RA.
Abstract

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