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Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092
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Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092

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A direct link between carbohydrate utilization and virulence in the major human pathogen group A Streptococcus

Samuel A Shelburne1, David Keith, Nicola Horstmann

  • 1Departments of Medicine and Pathology, Baylor College of Medicine, Houston, TX 77030, USA.

Proceedings of the National Academy of Sciences of the United States of America
|January 31, 2008
PubMed
Summary

Group A Streptococcus (GAS) virulence is linked to carbohydrate metabolism via catabolite control protein A (CcpA). This regulator impacts virulence factor production and colonization, offering insights into pathogen mechanisms.

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