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Clinical study on pharmacological interaction between nimesulide and warfarin
1Division of Clinical Immunology and Allergology, University of Siena, Italy.
International Journal of Clinical Pharmacology Research
|January 1, 1991
Summary
Nimesulide, a non-steroidal anti-inflammatory drug, does not significantly alter warfarin
Area of Science:
- Pharmacology
- Drug Interactions
- Internal Medicine
Background:
- Nimesulide is a non-steroidal anti-inflammatory drug (NSAID).
- Warfarin is an indirect anticoagulant.
- Previous studies suggested potential potentiation of warfarin by NSAIDs.
Purpose of the Study:
- To investigate the pharmacological interaction between nimesulide and warfarin.
- To determine if nimesulide potentiates the anticoagulant activity of warfarin.
- To assess the short-term bleeding risk associated with the co-administration of nimesulide and warfarin.
Main Methods:
- Ten patients on a stable warfarin dose (5 mg/day) were enrolled.
- Nimesulide (100 mg twice daily) was administered for seven days.
- Prothrombin time (PT), partial thromboplastin time (PTT), fibrinogen levels, and bleeding time were measured.
Main Results:
- Co-administration of nimesulide and warfarin did not result in statistically significant changes in PT or PTT.
- Fibrinogenemia and bleeding time remained unaltered.
- No increased bleeding risk was observed during the short-term treatment period.
Conclusions:
- Short-term treatment with nimesulide does not appear to potentiate warfarin's anticoagulant effect.
- Combining warfarin with nimesulide at the studied doses and duration does not pose an increased bleeding risk.
- Further studies may be warranted to explore long-term interactions.