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Perforated synapses and plasticity. A developmental overview.

D G Jones1, W Itarat, R K Calverley

  • 1Department of Anatomy, University of Otago, Dunedin, New Zealand.

Molecular Neurobiology
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

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Perforated and nonperforated synapses are distinct populations in the rat neocortex. Perforated synapses maintain neuronal postsynaptic density surface area in adulthood, suggesting a key role in synaptic plasticity.

Area of Science:

  • Neuroscience
  • Synaptic Plasticity
  • Developmental Biology

Background:

  • Existing models link perforated synapses to synaptic plasticity.
  • The developmental trajectory and function of perforated synapses remain incompletely understood.

Purpose of the Study:

  • To quantify the numerical density and frequency of perforated synapses in rat neocortex across development (1 day to 22 months).
  • To analyze morphological changes in perforated synapses using 3-D reconstructions.
  • To investigate the role of perforated synapses in maintaining neuronal structure and function.

Main Methods:

  • Utilized the disector procedure for stereological quantification of synapse density.
  • Employed 3-D computer reconstructions to assess synaptic morphology.

Related Experiment Videos

  • Studied synapse populations in rat neocortex across a wide age range.

    • Main Results:

    • Perforated and nonperforated synapses appear as distinct populations early in development.
    • Perforated synapses contribute to maintaining neuronal postsynaptic density surface area from mid-adulthood.
    • Evidence suggests a crucial role for perforated synapses in synaptic plasticity.

    Conclusions:

    • Perforated synapses are a distinct population with a specific developmental trajectory.
    • These synapses are vital for maintaining neuronal structure in adult brains.
    • Their precise role in synaptic plasticity may differ from current hypotheses.