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Updated: Jul 7, 2026

Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice
Published on: December 8, 2023
Allogeneic hematopoietic stem cell transplantation using a reduced-intensity conditioning regimen in infants:
Oscar Gonzalez Llano1, José Carlos Jaime Perez, Olga Cantu Rodriguez
1Pediatric Department and Hematology Service, School of Medicine and University Hospital, "Dr. Jose E. Gonzalez," Universidad Autonoma de Nuevo Leon, Monterrey, Mexico. ogzzll25@hotmail.com
Abstract:
The authors report their experience with allogeneic hematopoietic stem cell transplantation in infants at a university hospital in México. Five infants had one of each of the following diagnoses: acute lymphoblastic leukemia, osteopetrosis for which the patient underwent 2 procedures, acute disseminated multiorgan Langerhans cell histiocytosis, and two cases of hemophagocytic lymphohistiocytosis. The source of stem cells for grafting in 2 children was peripheral blood, and in 3 children was unrelated cord blood. A reduced-intensity conditioning regimen including fludarabine, cyclophosphamide, and melphalan was administrated. Three patients are disease-free transplant survivors without graft-versus-host disease after 46, 34, and 16 months.
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