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Pyrazinamide induced hyperuricaemia presenting as severe bilateral leg cramps
Seema Gupta1, Vikram Gupta, B Kapoor
1Postgraduate Department of Pharmacology and Therapeutics, Government Medical College, Jammu.
Journal of the Indian Medical Association
|February 1, 2008
Summary
Pyrazinamide, a tuberculosis drug, commonly causes hyperuricaemia, leading to gout. This case highlights bilateral leg cramps as an unusual presentation of pyrazinamide-induced hyperuricaemia.
Area of Science:
- Pharmacology
- Nephrology
- Rheumatology
Background:
- Pyrazinamide is a crucial first-line medication for tuberculosis treatment.
- Common adverse effects include hepatotoxicity and hyperuricaemia.
- Hyperuricaemia arises from inhibited urate elimination, potentially causing gout.
Observation:
- This report details a patient experiencing bilateral leg cramps.
- The leg cramps were a direct consequence of hyperuricaemia.
- The hyperuricaemia was induced by pyrazinamide therapy.
Findings:
- Pyrazinamide therapy can lead to significant hyperuricaemia.
- Hyperuricaemia may manifest with atypical symptoms beyond arthralgia and gout.
- Bilateral leg cramps represent a novel clinical presentation of this condition.
Implications:
- Clinicians should consider pyrazinamide-induced hyperuricaemia in patients presenting with unexplained leg cramps.
- Monitoring urate levels may be important in patients on long-term pyrazinamide treatment.
- This case expands the known spectrum of pyrazinamide's adverse effects.
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