[Effects of topical treatment with Bostrombin ointment and gel in model rabbits]

In the study with preparations under the registered names Bostrombin gel 50,000 IU and Bostrombin ointment 50,000 IU, in two parallel groups we did one-time and several times application of drugs to the health and previously damaged skin of rabbits. The study included 24 rabbits, divided in 4 groups with 6 rabbits. In two groups of rabbits 3 hour before application the skin was damaged. The skin was treated with gel or ointment, supervised after 15 minutes, and every hour first 6 hours. Also, skin was examined after 24, 48 and 72 hour. Four day after one-time application same rabbits were treated seven days with Bostrombin gel and ointment preparations, after seven days we made notes of effects to skin. The research confirmed that one-time application Bostrombin gel and ointment at health and damaged skin has no effect, but several times application of drug on damaged skin provoke reaction such as eritema and red inflammation of skin. We tested the efficacy, tolerance and impact of topical therapy with Bostrombin gel and ointment at health and damaged skin of rabbits.