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Related Concept Videos

Decreased pulse rate01:14

Decreased pulse rate

Bradycardia is a medical condition in which the heart rate is slower than normal. It occurs when the heart's natural pacemaker, the sinus node, generates slower electrical impulses than the standard rhythm. In adults, bradycardia is diagnosed when the pulse rate falls below 60 beats per minute, indicating a deviation from the normal heart rate range.
There are specific risk factors that can elevate the likelihood of developing bradycardia. Advanced age is a significant factor, with bradycardia...
Pulse01:16

Pulse

When the heart pumps blood out, arterial elastic fibers play a crucial role in sustaining a high-pressure gradient. They expand to accommodate the received blood and then recoil - a process known as the pulse that can be either manually palpated or electronically quantified. Despite a reduction in its effect with increased distance from the heart, elements of the pulse's systolic and diastolic components persist, observable even at the arteriole level.
The pulse serves as a clinical indicator...
Pulse01:05

Pulse

The pulse is one of the most fundamental physiological indicators of the body's cardiovascular health. It is the rhythmic expansion and contraction of the arterial walls in response to the pressure generated by the heart's pumping action.
Pulse Rate and its Significance
Pulse rate, often measured in beats per minute (bpm), reflects the heart rate (HR), which is influenced by numerous factors such as stress, physical activity, and hormonal changes. A normal resting adult pulse rate falls between...
Special considerations while measuring pulse01:13

Special considerations while measuring pulse

Assessing a patient's pulse is a fundamental skill in healthcare, but certain situations require special attention:
Pulse amplitude and quality01:17

Pulse amplitude and quality

Pulse amplitude is a crucial indicator of cardiac health because it provides valuable insights into the strength of left ventricular contractions and the overall uniformity of blood circulation within the vasculature. The strength of the pulse is directly related to the force with which the heart contracts and the volume of blood being pumped.
A weak or absent pulse may indicate reduced cardiac output or poor left ventricular contraction, which can be signs of cardiovascular dysfunction or...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...

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Related Experiment Video

Updated: Jul 7, 2026

Novel and Innovative Hybrid Technique for Type A Aortic Dissection
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Novel and Innovative Hybrid Technique for Type A Aortic Dissection

Published on: March 28, 2025

[Takayasu disease--pulseless disease].

Keiji Sano1

  • 1Department of Neurosurgery, Tokyo Neuro Center, Minato-ku, Tokyo, Japan.

Brain and Nerve = Shinkei Kenkyu No Shinpo
|February 1, 2008
PubMed
Summary

Takayasu arteritis, also known as Pulseless Disease, is a chronic arteritis affecting major arteries. Research indicates it involves autoimmune responses with immune interferon and specific gamma globulin in patient sera.

Area of Science:

  • Vascular Biology
  • Immunology
  • Ophthalmology

Context:

  • Historically documented by Takayasu in 1908 focusing on retinal vascular changes.
  • Further characterized by Shimizu and Sano in 1948 as a chronic arteritis affecting the aortic arch and its branches, termed 'Pulseless Disease'.
  • The disease presents with a distinct triad: absent radial pulse, carotid sinus hyperactivity, and hypotensive ophthalmopathy.

Purpose:

  • To elucidate the underlying pathological mechanisms of Takayasu arteritis.
  • To identify key clinical manifestations and diagnostic criteria.
  • To investigate the immunological basis of the disease.

Summary:

  • Takayasu arteritis is a chronic inflammatory condition primarily affecting the aorta and its major branches.

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Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat
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Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat

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Last Updated: Jul 7, 2026

Novel and Innovative Hybrid Technique for Type A Aortic Dissection
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Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat
08:34

Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat

Published on: November 18, 2018

  • Clinical presentation includes the characteristic triad of absent pulse, carotid sinus reflex abnormalities, and ocular vascular changes.
  • Immunological studies revealed the presence of immune interferon and autoantibodies (gamma globulin) reacting with arterial wall components in affected patients, suggesting an autoimmune etiology.

    • Impact:

    • Improved understanding of the autoimmune nature of Takayasu arteritis.
    • Enhanced diagnostic criteria and clinical recognition of Pulseless Disease.
    • Foundation for further research into targeted immunotherapies for large vessel vasculitis.