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Updated: Jul 7, 2026
08:14
Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting
Published on: September 25, 2012
[Revised WHO classification of brain tumours]
1Department of Human Pathology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
Brain and Nerve = Shinkei Kenkyu No Shinpo
|February 1, 2008
Summary
The 2007 WHO classification of brain tumors was updated, introducing new tumor types and histological variants. This revision impacts daily medical practice and tumor diagnosis.
Area of Science:
- Neuropathology
- Oncology
- Medical Diagnostics
Context:
- The World Health Organization (WHO) classification of brain tumors is a cornerstone in neuro-oncology.
- Previous editions have guided diagnosis and research for over two decades.
- The 2007 revision represents a significant update to this established system.
Purpose:
- To review the major changes introduced in the 4th edition of the WHO classification of brain tumors.
- To provide an overview of newly codified entities and reclassified tumors.
- To comment on the alterations in grading concepts and terminology.
Summary:
- The 4th edition of the WHO classification (2007) introduced new brain tumor entities such as atypical choroid plexus papilloma and angiocentric glioma.
- It also redefined histological variants based on clinical, genetic, or prognostic differences, including pilomyxoid astrocytoma.
- Terminology and tumor reclassifications were updated, affecting diagnostic criteria.
Impact:
- This revised classification impacts daily medical practice, research, and the understanding of brain tumor heterogeneity.
- It provides a more refined framework for diagnosing and treating various brain tumors.
- The updated terminology and entity codification facilitate clearer communication among clinicians and researchers.
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