Related Experiment Video
Updated: Jul 7, 2026

10:49
Confocal Laser Scanning Microscopy of Calcium Dynamics in Acute Mouse Pancreatic Tissue Slices
Published on: April 13, 2021
[A novel method for automated detection of activation time]
Culying Zhang1, Shangjun Zhang, Yan Li
1Shandong Province Chest Hospital, No. 46 Lishan Rd. Ji'nan 250013, China.
Summary
Determining cardiac activation times is slow. This study introduces a new method using unipolar and bipolar electrograms for accurate, faster local activation time determination in cardiac studies.
Area of Science:
- Cardiology
- Biomedical Engineering
- Electrophysiology
Background:
- Manual determination of local activation times is time-consuming.
- This limitation hinders real-time application in clinical procedures and electrophysiologic experiments.
Purpose of the Study:
- To develop a novel, accurate, and efficient method for determining local activation times.
- To overcome the limitations of manual determination in cardiac activity analysis.
Main Methods:
- The study presents a novel algorithm integrating former bipolar and unipolar algorithms.
- Simultaneous analysis of unipolar and bipolar electrograms is employed.
- This approach aims to improve the accuracy of activation time determination.
Main Results:
- The novel method demonstrates good accuracy in determining local activation times.
- The approach offers a more efficient alternative to manual methods.
Conclusions:
- The proposed method provides an accurate and efficient solution for local activation time determination.
- This advancement facilitates the application of cardiac activity analysis in clinical and experimental settings.

