An aqueous extract of guaraná (Paullinia cupana) decreases platelet thromboxane synthesis
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S P Bydlowski1, E A D'Amico, D A Chamone
1Fundação Pró-Sangue Hemocentro de São Paulo, Faculdade de Medicina, Universidade de São Paulo, Brasil.
Abstract:
The effects of an aqueous extract of guaraná (Paullinia cupana) on rabbit platelet aggregation and thromboxane synthesis were examined. The guaraná extract (100 mg/ml) and fractions separated by TLC (origin and xanthines) decreased platelet aggregation (37, 27 and 31% of control values, respectively) and platelet thromboxane formation from [14C]-arachidonic acid (78, 70 and 50% of control values, respectively). The decreased thromboxane synthesis could be responsible, at least in part, for the antiaggregatory action of guaraná.