Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

One-Compartment Model: IV Infusion

One-Compartment Model: IV Infusion

Intravenous (IV) infusion is often utilized when continuous and controlled drug delivery is necessary, such as during surgery or in the treatment of chronic diseases. This method offers numerous advantages, including immediate drug action, precise control over dosage, and bypassing the first-pass metabolism.
The one-compartment model for IV infusion uses mathematical equations to describe the rate of change in drug quantity in the body. At steady-state or infusion equilibrium, the drug input...

IV Infusion to Oral Dosing: Conversion Methods

IV Infusion to Oral Dosing: Conversion Methods

The development of extended-release formulations has facilitated the transition from intravenous to oral medication, offering a more convenient and patient-friendly approach to drug administration. This transition, however, requires careful management to ensure that therapeutic drug levels are maintained, preserving efficacy and avoiding adverse effects. Understanding pharmacokinetic principles and dosage calculations is critical during this process.Pharmacokinetics of the...

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...

Two-Compartment Open Model: IV Infusion

Two-Compartment Open Model: IV Infusion

A two-compartment model is a vital tool in pharmacokinetics, providing an essential understanding of drug behavior, especially for those administered via zero-order intravenous infusion. This model outlines two compartments: the central compartment, where elimination occurs, and the peripheral compartment.
The model illustrates the decrease in plasma drug concentration from the central compartment with a specific equation. It shows that under steady-state conditions, the drug's input rate...

Drug Dosing: Infants and Children

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

PDA Stenting May Be a Favorable Alternative to BTT Shunt Regarding Acute Complications and Mid Term Pulmonary Artery Growth.

Pediatric cardiology·2025

Same author

Cerebral air embolism in pediatric patients undergoing cardiac surgery.

Journal of cardiothoracic surgery·2024

Same author

To Tube or Not to Tube ... That Continues to Be the Question.

Air medical journal·2023

Same author

Protective effect of soluble Klotho in pediatric patients undergoing cardiac surgery with cardiopulmonary bypass support-A pilot study.

Journal of cardiac surgery·2021

Same author

Whole-exome sequencing reveals a monogenic cause in 56% of individuals with laterality disorders and associated congenital heart defects.

Journal of medical genetics·2021

Same author

Catheter-directed thrombolysis for in situ pulmonary artery thrombosis in children.

Annals of pediatric cardiology·2021

Search research articles

Related Experiment Video

Updated: Jul 7, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

Infant intraosseous infusion.

Scott DeBoer¹, Terri Russell, Michael Seaver

¹University of Chicago Hospitals, USA. scott@peds-r-us.com

Neonatal Network : NN

|February 1, 2008

Summary

Intraosseous (IO) infusion offers a critical alternative when intravenous (IV) access is difficult in newborns. This method provides rapid fluid and medication delivery for critically ill infants when other vascular access fails.

Area of Science:

Neonatal Medicine
Pediatric Critical Care
Emergency Medicine

Background:

Umbilical cord access is common for neonates but often unavailable after the immediate newborn period.
Peripheral intravenous (IV) access can be challenging to establish in critically ill newborns.
Intraosseous (IO) infusion is an underutilized but effective alternative vascular access method in neonates.

Purpose of the Study:

To review the utility of intraosseous (IO) infusion in neonatal care.
To describe available IO infusion devices and optimal placement sites for infants.
To outline the assessment and management of neonates receiving IO therapy.

Main Methods:

Literature review of intraosseous (IO) infusion in neonatal populations.

More Related Videos

Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.

Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.

Published on: March 17, 2008

Assessment of the Efficacy of An Osteopathic Treatment in Infants with Biomechanical Impairments to Suckling

Assessment of the Efficacy of An Osteopathic Treatment in Infants with Biomechanical Impairments to Suckling

Published on: February 5, 2019

Related Experiment Videos

Last Updated: Jul 7, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.

Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.

Published on: March 17, 2008

Assessment of the Efficacy of An Osteopathic Treatment in Infants with Biomechanical Impairments to Suckling

Assessment of the Efficacy of An Osteopathic Treatment in Infants with Biomechanical Impairments to Suckling

Published on: February 5, 2019

Analysis of IO device technology and anatomical considerations for neonatal placement.

Discussion of clinical protocols for IO fluid and medication administration in neonates.

Main Results:

IO infusion provides rapid and reliable vascular access when IV access is not feasible in neonates.
Various IO devices are available, with specific sites recommended for neonatal anatomy.
Careful monitoring and management are essential for infants receiving IO infusions.

Conclusions:

Intraosseous (IO) infusion is a valuable and viable resuscitation tool for critically ill neonates.
Healthcare providers should be familiar with IO techniques for timely vascular access.
Expanding the use of IO infusion can improve outcomes for neonates requiring urgent vascular access.