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Bacterial hosts for natural product production

Haoran Zhang1, Yong Wang, Blaine A Pfeifer

  • 1Department of Chemical and Biological Engineering, Tufts University, Medford, Massachusetts 02155, USA.

Molecular Pharmaceutics
|February 1, 2008
PubMed
Summary

This review evaluates four bacterial hosts—Escherichia coli, Bacillus subtilis, pseudomonads, and Streptomyces—for producing therapeutic natural products. It assesses their suitability for both native and heterologous biosynthesis of polyketides, nonribosomal peptides, terpenoids, and flavonoids.

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