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Updated: Jul 7, 2026

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
Total syntheses of clausamines A-C and clausevatine D
Terry P Lebold1, Michael A Kerr
1Department of Chemistry, The University of Western Ontario, London, Ontario, Canada N6A 5B7.
Abstract:
The first total syntheses of clausamines A-C and clausevatine D are reported. The key step involves a Diels-Alder reaction between an imine quinone and cyclic diene, allowing for the subsequent construction of the carbazole core in a regiospecific manner. Stereochemistry of the natural products is also discussed.
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