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Suppression of the IgE antibody response by Ascaris suum components: effect of X-irradiation
M F Soares1, I Mota, M S Macedo
1Centro de Pesquisa e Formação em Imunologia, Instituto Butantan, São Paulo, Brasil.
The effect of X-irradiation on the suppression of IgE antibody responses induced by some of the Ascaris suum (ASC) components was analyzed in mice (7-week old A/Sn females). Treatment with 300 R 24 h before immunization with 50 micrograms OVA and 200 micrograms ASC suppressive components abolished the damping effect on anti-OVA IgE antibody levels. The same effect was observed on the anti-ASC IgE antibody response obtained in mice injected with 200 micrograms ASC immunogenic plus 200 micrograms ASC suppressive components. Moreover, the failure of suppressive components to induce an IgE anti-ASC antibody response on their own was also abolished by X-irradiation. These results indicate that the suppressive components are able to elicit an IgE antibody response, but simultaneously activate a regulatory mechanism which suppresses both the homologous (anti-ASC) and heterologous (anti-OVA) antibody formation.
The effect of X-irradiation on the suppression of IgE antibody responses induced by some of the Ascaris suum (ASC) components was analyzed in mice (7-week old A/Sn females). Treatment with 300 R 24 h before immunization with 50 micrograms OVA and 200 micrograms ASC suppressive components abolished the damping effect on anti-OVA IgE antibody levels. The same effect was observed on the anti-ASC IgE antibody response obtained in mice injected with 200 micrograms ASC immunogenic plus 200 micrograms ASC suppressive components. Moreover, the failure of suppressive components to induce an IgE anti-ASC antibody response on their own was also abolished by X-irradiation. These results indicate that the suppressive components are able to elicit an IgE antibody response, but simultaneously activate a regulatory mechanism which suppresses both the homologous (anti-ASC) and heterologous (anti-OVA) antibody formation.
