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Updated: Jul 7, 2026

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
Published on: May 6, 2010
Experiments confirm the influence of genome long-range correlations on nucleosome positioning
C Vaillant1, B Audit, A Arneodo
1Laboratoire Joliot-Curie and Laboratoire de Physique, CNRS, ENS-Lyon, 46 Allée d'Italie, 69364 Lyon Cedex 07, France.
Abstract:
From the statistical analysis of nucleosome positioning data for chromosome III of S. cerevisiae, we demonstrate that long-range correlations (LRC) in the genomic sequence strongly influence the organization of nucleosomes. We present a physical explanation of how LRC may significantly condition the overall formation and positioning of nucleosomes including the nucleosome-free regions observed at gene promoters. From grand canonical Monte Carlo simulations based upon a simple sequence-dependent nucleosome model, we show that LRC induce a patchy nucleosome occupancy landscape with alternation of "crystal-like" phases of confined regularly spaced nucleosomes and "fluidlike" phases of rather diluted nonpositioned nucleosomes.
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